The understanding of molecular mechanisms and genetic networks that protect the host from infections by pathogens is still incomplete. A quantitative comprehension of fundamental principles of the mammalian immune response is essential to explain how innate and adaptive immunity responds to infectious challenges, and how regulatory circuitries and molecular switches work to defend against invading pathogens.

Within this Cluster, we initiated collaborative studies to identify common principles in the immune response against different bacterial and eukaryotic pathogens. We hereby wish to identify key signalling molecules and pathogen recognition receptors as well as pathogen-specific pathways leading to the protection of mammalian hosts against infectious microbes such as major bacterial and eukaryotic fungal pathogens.


Arndt von Haeseler, PhD
Center for Integrative Bioinformatics Vienna (CIBIV)
Max F. Perutz Laboratories (MFPL)
Campus Vienna Biocenter 5 (VBC5), Ebene 1
A-1030 Wien, Austria
Phone: ++43 +1 / 4277 - 24007

Sylvia Knapp, MD, PhD
Department of Medicine 1,
Laboratory of Infection Biology
Medical University of Vienna
& Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences
Währinger Gürtel 18-20, 1090 Vienna
Phone: +43-1-40400-5139